Hepatotoxicity Associated With Vismodegib

Hepatotoxicity associated with statins.

Fatal hepatotoxicity associated with 6-mercaptopurine therapy.

Hepatotoxicity Associated with Herbal Tea Containing Kelp

A 40-yr-old Sri Lankan female presented to the gastroenterology clinic with jaundice. Further work-up revealed extrahepatic cholestasis with a hepatocellular component; however, subsequent work-up revealed no significant findings. Hospitalization revealed hepatotoxicity associated with ingestion of a homemade herbal tea containing kelp (Laminaria), which was confirmed with further history. Hepa...

Icodextrin-associated hepatotoxicity

Icodextrin-associated hepatotoxicity Sir, Abnormal liver function tests can be observed in peritoneal dialysis (PD) patients. The most common cause of these are viral infections, especially hepatitis B and C [1]. Icodextrin-based PD solutions (Extraneal; Baxter, IL, USA) are increasingly used in this patient population [2]. Several adverse reactions have been reported with icodex-trin, mainly s...

Hepatotoxicity with Vismodegib: An MD Anderson Cancer Center and Research on Adverse Drug Events and Reports Project

BACKGROUND On 30 January 2012, the US FDA approved vismodegib (Erivedge®, Genentech, CA, USA) for the management of both metastatic and locally advanced basal cell carcinoma. OBJECTIVE Our objective was to identify evidence of hepatotoxicity with vismodegib in the FDA Adverse Event Reporting System (FAERS) in treated patients in two National Cancer Institute Comprehensive Cancer Centers. ME...